Graduate Research School Available Projects Mathematical Modelling of Cell-Fate Determination
Mathematical Modelling of Cell-Fate Determination
- Future Students
- JCU Global Experience
- International Students
- Open Day
- How to apply
- Pathways to university
- Virtual Open Day
- Living on Campus
- Courses
- Publications
- Scholarships
- Parents and Partners
- JCU Heroes Programs
- Aboriginal and Torres Strait Islander in Marine Science
- Elite Athletes
- Defence
- AI@JCU
- Current Students
- New students
- JCU Orientation
- LearnJCU
- Placements
- CEE
- Unicare Centre and Unicampus Kids
- Graduation
- Off-Campus Students
- JCU Job Ready
- Safety and Wellbeing
- JCU Prizes
- Professional Experience Placement
- Employability Edge
- Art of Academic Writing
- Art of Academic Editing
- Careers and Employability
- Student Equity and Wellbeing
- Career Ready Plan
- Careers at JCU
- Partners and Community
- JCU-CSIRO Partnership
- Alumni
- About JCU
- Reputation and Experience
- Chancellery
- Governance
- Celebrating 50 Years
- Academy
- Indigenous Engagement
- Education Division
- Graduate Research School
- Research and Teaching
- Research Division
- Research and Innovation Services
- CASE
- College of Business, Law and Governance
- College of Healthcare Sciences
- College of Medicine and Dentistry
- College of Science and Engineering
- CPHMVS
- Anthropological Laboratory for Tropical Audiovisual Research (ALTAR)
- Anton Breinl Research Centre
- Agriculture Technology and Adoption Centre (AgTAC)
- Advanced Analytical Centre
- AMHHEC
- Aquaculture Solutions
- AusAsian Mental Health Research Group
- ARCSTA
- Area 61
- Lions Marine Research Trust
- Australian Tropical Herbarium
- Australian Quantum & Classical Transport Physics Group
- Boating and Diving
- Clinical Psychedelic Research Lab
- Centre for Tropical Biosecurity
- Centre for Tropical Bioinformatics and Molecular Biology
- CITBA
- CMT
- Centre for Disaster Solutions
- CSTFA
- Cyclone Testing Station
- The Centre for Disaster Studies
- Daintree Rainforest Observatory
- JCU Eduquarium
- JCU Turtle Health Research
- Language and Culture Research Centre
- MARF
- Orpheus
- TESS
- JCU Ideas Lab
- TARL
- eResearch
- Indigenous Education and Research Centre
- Estate
- Work Health and Safety
- Staff
- Discover Nature at JCU
- Cyber Security Hub
- Association of Australian University Secretaries
- Services and Resources Division
- Environmental Research Complex [ERC]
- Foundation for Australian Literary Studies
- Gender Equity Action and Research
- Give to JCU
- Indigenous Legal Needs Project
- Inherent Requirements
- IsoTropics Geochemistry Lab
- IT Services
- JCU Webinars
- JCU Events
- JCU Motorsports
- JCU Sport
- Library
- Mabo Decision: 30 years on
- Marine Geophysics Laboratory
- Office of the Vice Chancellor and President
- Outstanding Alumni
- Pharmacy Full Scope
- Planning for your future
- Policy
- PAHL
- Queensland Research Centre for Peripheral Vascular Disease
- Rapid Assessment Unit
- RDIM
- Researcher Development Portal
- Roderick Centre for Australian Literature and Creative Writing
- Contextual Science for Tropical Coastal Ecosystems
- State of the Tropics
- Strategic Procurement
- Student profiles
- SWIRLnet
- TREAD
- TropEco for Staff and Students
- TQ Maths Hub
- TUDLab
- VAVS Home
- WHOCC for Vector-borne & NTDs
- Media
- Copyright and Terms of Use
- Australian Institute of Tropical Health & Medicine
- Pay review
Title of Project
Mathematical Modelling of Cell-Fate Determination
Advisor/s
A/Prof Ulf Schmitz, Dr Daniel Xing, Prof Andreas Lopata
College or Research Centre
College of Medicine & Dentistry; College of Public Health, Medical & Veterinary Science
Summary of Project
Join our dynamic research team at JCU and the Townsville Cancer Centre (TCC) for an exciting HDR (Higher Degree by Research) project that merges cutting-edge technology with critical clinical applications. Our umbrella project encompasses two groundbreaking research initiatives aimed at improving cancer treatment outcomes and patient care. Project 1: Enhancing Glioblastoma Treatment with Magnetic Resonance and Radiotherapy Glioblastoma (GBM) remains one of the most aggressive brain cancers, with limited survival rates despite recent advances in treatment. Our research focuses on the novel application of tumour treating fields and the integration of a magnetic resonance linear accelerator (MRL) to explore the biological effects of combining magnetic fields with ionizing radiation. We aim to uncover how these combined modalities impact tumour and immune cell interactions, ultimately seeking to improve GBM treatment efficacy. Project 2: Developing Blood-Based Surveillance for HPV-Associated Oropharyngeal Cancer Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (HPV-OPSCC) presents unique challenges in post-treatment surveillance, particularly for patients in remote regions. Our research aims to develop and validate a blood-based circulating HPV-DNA (cHPV-DNA) test using next-generation sequencing (NGS). This innovative approach will enable earlier detection of recurrent disease, reduce patient burden, and improve survival outcomes for HPV-OPSCC patients.
We are seeking motivated and creative HDR candidates to join our research team to investigate the regulatory mechanisms of cellular differentiation through mathematical modelling. Cellular differentiation, the process by which cells acquire specialised functions, is a fundamental biological process that underlies many aspects of development and disease. The project aims to develop deterministic and/or stochastic mathematical models that describe the regulatory mechanisms underlying cell-fate determination, and to use these models to gain insights into how cells make fate decisions in response to various internal and external environments. In addition, the successful candidate will work with data from various sequencing technologies such as bulk RNA sequencing, single-cell sequencing, and long-read sequencing to validate the developed models.
The ideal candidate should have a background in mathematics, computer science, engineering, bioinformatics, computational biology, or a related field. The project will involve model development, numerical analyses, and data analyses. The candidate will use these models to explore the effects of different genetic and environmental factors on cell-fate decisions, and to identify key regulators of cellular differentiation. The candidate will also be responsible for analysing and interpreting the model results and writing up their findings for publication in high-impact academic journals.
Key Words
brain cancer; head and neck cancer; radiation oncology; biomarker; bioinformatics next generation sequencing
Would suit an applicant who
We invite motivated students with a passion for oncology, molecular biology, and innovative technology to apply. This is a unique opportunity to contribute to transformative research with the potential to significantly impact patient care and treatment outcomes.
has a background in mathematics, computer science, engineering, bioinformatics, computational biology, or a related field. This project is suitable for doctoral or master students. Some computational skills (MATLAB, Python, R programming) would be very helpful.
Updated: 17 Mar 2023